Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 GenomeResearch Article Published on 2021-08-032022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] Coronavirus, SARS, [키워드] assays binding Compound conserved COVID19-NMR defined druggability effective element elements experiments fragment screening functional Genome group in vivo Ligand NMR NMR spectroscopy nuclear nucleotides performed positive Region Regulatory RNA RNA genome RNAs SARS-CoV-2 SARS‐CoV‐2 targets [DOI] 10.1002/anie.202103693 PMC 바로가기 [Article Type] Research Article